MODULATION OF THE SYSTEM IN SEROTONINERGIC PARKINSON'S DISEASE: THERAPEUTIC APPLICATIONS IN BASIC AND CLINICAL RESEARCH

Jean Carlos Souza Silva, Antonio William do Nascimento Fernandes, Dayane Pessoa de Araújo

Résumé


Serotonin, also called 5-hydroxytryptamine is a neurotransmitter synthesized from dietary tryptophan regulatory having high potential in human tissues. 5-HT can act as a neurotransmitter in nerve fibers of fixed catalyst homeostatic responses and central nervous system can control cognition, emotion and motor behavior. The present study is an investigation of the main applications and intervene. Therapeutic enções described in publications about the serotonergic modulation in patients with Parkinson's disease in different stages as well as the experimental animal studies induced parkinsonism. The study leads to an update of the main therapeutic targets as serotonin transporter, serotonin receptor tissue, among others.

 


Mots-clés


Serotonin; 5-HT, Parkinson's disease; Neurodegeneration

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Revista Brasileira de Neurologia e Psiquiatria. ISSN: 1414-0365